Highlights include results from two score models that accurately predicted successful weaning from mechanical circulatory support in patients with cardiogenic shock. There is also a study on the various indications, modalities, and considerations essential for the use of kidney replacement therapies as well as addressing unique clinical scenarios in treating patients with advanced heart failure.
WASHINGTON, DC (MAY 13, 2025) – Advancements in mechanical circulatory support (MCS) capabilities have led to increasing numbers of patients in the acute phase of cardiogenic shock or advanced heart failure (HF) receiving these lifesaving treatments. Various predictors or weaning strategies for MCS have been reported, however, no guidance has been established. A validated model that accurately predicted successful weaning from MCS could be useful for bedside determination of whether to decannulate MCS, consider advanced therapy, or withdraw care.
The Journal of Cardiac Failure May 2025 issue, now online, includes updates on 2 weaning score models that included acute myocardial infarction, mean blood pressure, left ventricular ejection fraction, lactate level, and QRS duration as variables.
“The May issue of JCF puts forth key articles that translate directly into clinical practice. Two ‘can’t miss’ papers include one that summarizes key models to help support MCS weaning, and the other is a state-of-the-art review on kidney replacement therapies in advanced HF. We are proud to publish articles like these that can directly translate to care for some of our sickest patients living with HF” said JCF co-editors-in-chief, Anuradha Lala, MD and Robert J. Mentz, MD.
Key Highlights include:
A Novel Predictive Score Model for Successful Weaning from Mechanical Circulatory Support in Patients with Cardiogenic Shock
Kidney Replacement Therapies in Advanced Heart Failure: Timing, Modalities and Clinical Considerations
Two score models were developed that accurately predicted successful weaning from mechanical circulatory support (MCS) in patients with cardiogenic shock. The first, the MCS weaning score enabled calculating each patient's predictive rate of successful weaning from MCS. The second, the simple MCS weaning score, accurately discriminated between patients who are likely to be successfully weaned from MCS and those with a high probability of MCS reintroduction or death after decannulation.
Acute kidney dysfunction is commonly encountered in patients with advanced heart failure, and it can affect treatment decisions and patient outcomes. This review discusses the intricacies of how to optimize timing and choose among the various kidney replacement therapy modalities along with a detailed discussion of the unique clinical scenarios that clinicians may face when treating this vulnerable patient group. .
The full line-up is as follows:
Original Research Papers
- Integration of Patient Reported Quality-of-Life Data into Risk Assessment in Heart Failure
- Prognostic Utility and Cutoff Differences of NT-proBNP Level Across Subgroups in Heart Failure With Preserved Ejection Fraction: Insights From the PURSUIT-HFpEF Registry
- Prevalence and Prognostic Implications of Changes in Tricuspid Regurgitation Severity in Acute Heart Failure
- Novel Predictive Score Model for Successful Weaning from Mechanical Circulatory Support in Patients With Cardiogenic Shock
- Equal Treatment, Unequal Outcomes? Debunking the Racial Disparity in Renin Angiotensin Aldosterone System Inhibitor–Associated Reduction in Heart Failure Hospitalizations
- The Psychometric Performance of the Kansas City Cardiomyopathy Questionnaire-12 in Symptomatic Obstructive Hypertrophic Cardiomyopathy
Methodology and Design
State-of-the-Art-Review
Perspectives
- PCWL: A Compelling Hemodynamic Metric in Advancing HFpEF Diagnosis
- Innovate and Translate: Highlights from Technology and Heart Failure Therapeutics, 2025, in Boston
Brief Reports
- ExCITe: A Narrative Review of Motivating Factors for Residency and Fellowship Selection to Provide Insights Regarding the Waning Interest in Advanced Heart Failure and Transplant Cardiology Training
- Practice Variation in Temporary Mechanical Circulatory Support for Cardiogenic Shock
- Implementation of a Digital Disease Management Platform for Heart Failure: AMAZE
Research Letter
JCF Ignite!
View the full issue online. For interviews with authors, please contact Alyssa Altonen at aaltonen@hfsa.org.
About the Journal of Cardiac Failure
The Journal of Cardiac Failure (JCF) publishes the highest quality science in the field of heart failure with a focus on diversity, equity, and inclusion, mentorship, multidisciplinary partnerships, and patient-centeredness. Published papers span original investigator-initiated work to state-of-the-art reviews, guidelines and scientific statements, expert perspectives, early career and trainee spotlight pieces, patient and patient-partner narratives. JCF also emphasizes the power of language and prioritizes innovative approaches to dissemination of published work to reach and impact the broader heart failure community.
About the Heart Failure Society of America
The Heart Failure Society of America, Inc. (HFSA) represents the first organized effort by heart failure experts from the Americas to provide a forum for all those interested in heart function, heart failure, and congestive heart failure (CHF) research and patient care. The mission of HFSA is to provide a platform to improve and expand heart failure care through collaboration, education, innovation, research, and advocacy. HFSA members include physicians, scientists, nurses, nurse practitioners, pharmacists, trainees, other healthcare workers and patients. For more information, visit hfsa.org.
Media Contact: Laura Poko, 301-798-4493, ext. 226, lpoko@hfsa.org